LAS190792 [CAS 1347232-69-2]

LAS190792 (AZD8999) is a potent muscarinic antagonist and β2-adrenoceptor agonist with pIC50 8.9, 8.8, 8.8, 9.2, 8.2, 7.5, 9.1, 5.6 for M1, M2, M3, M4, M5, β1, β2, β3, respectively. LAS190792 can be used as a bronchodilator[1].

[1347232-69-2]

C39H43ClN4O9S2

811.36

COC(C=C(NC(OCCN(C)[C@@H]1CC[C@@H](OC(C(O)(C2=CC=CS2)C3=CC=CS3)=O)CC1)=O)C(Cl)=C4)=C4CNC[C@H](O)C5=CC=C(O)C(N6)=C5C=CC6=O

Adrenergic Receptor; mAChR

MAChR1; mAChR2; mAChR3; mAChR4; mAChR5; β adrenergic receptor

10 mM in DMSO

Room temperature