LasR-IN-5

LasR-IN-5 (compound 3C) is a LasR antagonist with an IC50 of 1.37 μM, demonstrating a 77% inhibition of biofilm formation in Pseudomonas aeruginosa. LasR-IN-5 also exhibits quorum sensing (QS) inhibition activity and has potential applications in Pseudomonas aeruginosa infection research[1].

C21H20N4S

360.48

CN(CC1)CCN1C(C=C2)=CC=C2/C=C(C#N)/C3=NC4=CC=CC=C4S3

Antibiotic; Bacterial

Room temperature