LB244

LB244 is a homologue of BB-Cl-amidine, which is an orally effective STING inhibitor (EC50=0.8 μM) and can be used to inhibit STING-dependent inflammatory diseases. The pharmacokinetic properties of LB244 indicate limited oral activity in mice[1].

C30H27N5O5

537.57

O=C(N[C@@H](CCCCNC(C1=CC=C(O1)[N+]([O-])=O)=O)C2=NC3=CC=CC=C3N2)C(C=C4)=CC=C4C5=CC=CC=C5

STING

98.08

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature