LC-1-40

LC-1-40 is a PROTAC that selectively degrades NUDT1 (DC50=0.97 nM) . LC-1-40 selectively inhibits MYCN-induced tumor growth in mouse models. LC-1-40 also induces nucleotide damage and apoptosis in MYCN-associated tumors. LC-1-40 can be used in cancer research[1]. (Red: NUDT1 binder; Blue: CRBN ligand; Black: Linker) .

C49H48N8O6

844.96

O=C1CCC(C(N1)=O)N2C(C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CC5CCN(CC5)C(C6=CC=C(C=C6)C7=CC=C8N=CC(C(NC9CC9)=O)=C(C8=C7)NC%10=CC=CC=C%10)=O)=O

Apoptosis; DNA/RNA Synthesis; PROTACs

10 mM in DMSO

Room temperature