LCC-12 (formate)

LCC-12 (formate) is a copper (II) chelator and a derivative of the biguanide metformin. LCC-12 (formate) reduces its hydrogen peroxide-dependent oxidation of NADH to NAD+. LCC-12 (formate) reduces IL-1β, IL-2, IL-6, IL-8, and TNF-α levels, as well as JAK2, STAT2, and IL-1 receptor-associated kinase 4 (IRAK4) levels in primary human cytokine-activated monocyte-derived macrophages (MDMs). LCC-12 (formate) reduces the number of CD80+ and CD86+ cytokine-activated MDMs. LCC-12 LCC-12 (formate) improves survival in a mouse model of sepsis induced by LPS or cecal ligation and puncture[1].

C17H38N10O2

414.55

NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO

Interleukin Related; IRAK; JAK; NADH Dehydrogenase; STAT; TNF Receptor

99.9

-20°C (Powder, sealed storage, away from moisture)

Blue Ice