LEB-03-144 [CAS 2858812-89-0]

LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cancer cells[1].

[2858812-89-0]

C43H51N11O6

817.94

C=CCN1C(C2=C(N1C3=NC(C(C)(O)C)=CC=C3)N=C(N=C2)NC4=CC=C(C=C4)N5CCN(CC5)CCCNC(CCC6=CC=C(O6)N7CCN(CC7=O)C(C=C)=O)=O)=O

Wee1

10 mM in DMSO

Room temperature