Ledipasvir-d16

Ledipasvir-d16 (GS-5885-d16) is deuterium labeled Ledipasvir. Ledipasvir (GS-5885) is an inhibitor of the hepatitis C virus NS5A, with EC50s of 34 pM and 4 pM against genotype 1a and 1b replicon, respectively. Ledipasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.62 μM[3].

C49H38D16F2N8O6

905.1

O=C(OC)NC(C(N([C@@H](C1=NC=C(C2=CC(C(F)(F)C3=C4C=CC(C5=CC=C6N=C([C@@H]7N(C(C(NC(OC)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=O)[C@@]8([H])CC[C@]7([H])C8)NC6=C5)=C3)=C4C=C2)N1)C9)CC%109CC%10)=O)([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H]

HCV; Isotope-Labeled Compounds; SARS-CoV

Room temperature