LEM-14 [CAS 1814881-70-3]

LEM-14 is a potent and selective NSD2 inhibitor with an IC50 of 132 µM. LEM-14 has very weak activitv against NSD1 and has no activity against NSD3. LEM-14 inhibits fibrotic gene expression in ND but not DIO BMDMs. LEM-14 combined with ionizing radiation (IR) enhances the apoptosis rate and reduces the colony-formation ability of CRC cells. LEM-14 exhibits enhanced anti-tumor efficacy in Balb/c nude mice bearing LoVo cell xenografts when combined with ionizing radiation. LEM-14 has the potential for the research of multiple myeloma and colorectal cancer[1][2][3].

[1814881-70-3]

C25H26N4O4S

478.56

O=C1C(C2=C(CCCC2)S3)=C3NC(CN4CCN(C([C@H]5CC6=CC=CC=C6C(O5)=O)=O)CC4)=N1

Apoptosis; Histone Methyltransferase

NSD2/MMSET/WHSC1

98.02

DMSO : 50 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice

H302, H315, H319

H302, H315, H319