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Leptomycin A [CAS 87081-36-5]

Leptomycin A [CAS 87081-36-5]

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QM-0106058

£476.46 GBP
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Product Details

  • Description

    Leptomycin A, a Streptomyces metabolite, is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins. Leptomycin A suppresses HIV-1 replication. Less potent than Leptomycin B[1][2].

  • CAS Number

    [87081-36-5]

  • Molecular Formula

    C32H46O6

  • Molecular Weight

    526.7

  • Smiles

    O=C(O)/C=C(C)/C[C@H](C)[C@@H](O)[C@H](C)C([C@H](C)/C=C(C)/C=C/C[C@@H](C)/C=C(C)\C=C\[C@H]1[C@@H](C)C=CC(O1)=O)=O

  • Target

    Antibiotic; CRM1; HIV

  • Isoform

    HIV-1

  • Purity

    99

  • Solubility

    Methanol : 10 mg/mL (ultrasonic;warming)

  • Storage Conditions

    -20°C, 3 years; 4°C, 2 years (Powder)

  • Shipping Conditions

    Room Temperature

  • Hazard Statement

    H225-H301+H311+H331-H370

  • Precautions

    P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501
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Variant Variant total Quantity Price Variant total
1 mgQM-0106058
1 mgQM-0106058
£476.46/ea		 £0.00
£476.46/ea £0.00

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Leptomycin A [CAS 87081-36-5]

Leptomycin A is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.