LeuRS-IN-1 [CAS 1364914-72-6]

LeuRS-IN-1 is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively[1]. LeuRS-IN-1 inhibits human cytoplasmic LeuRS (IC50=38.8 μM), and HepG2 protein synthesis (EC50=19.6 μM) [2].

[1364914-72-6]

C10H13BClNO3

241.48

CCOC1=C2C([C@H](OB2O)CN)=C(C=C1)Cl

Bacterial

10 mM in DMSO

Room temperature