Lilial is a widely used synthetic fragrance and ester in consumer products. Lilial possesses estrogenic activity in vitro. Lilial can induce a toxic effect on mitochondria that causes a decrease in the viability of HaCaT cells. Lilial can increase NRF2 protein level in vitro. Lilial is able to target respiratory chain complexes, inhibit complexes I and II of the electron transport chain, increase the generation of reactive oxygen species, and decrease the level of intracellular ATP. Lilial can induce systemic toxicity in vivo. Lilial induces significant DNA strand breaks[1][2][3][4].
CAS Number
[80-54-6]
Molecular Formula
C14H20O
Molecular Weight
204.31
Smiles
O=CC(C)CC1=CC=C(C(C)(C)C)C=C1
Target
Keap1-Nrf2; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)