LIN28-IN-1

LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD) . LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC50: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC50: 6.4 μM) [1].

C40H38N6O7

714.77

OC(C1=CC=C(N2C(C(C=C([N+]([O-])=O)C(N3CCN(C(OCC4=CC=CC=C4)=O)CC3)=C5)=C5OC67CCN(CC8=CC=CC=C8)CC7)=C6C=N2)C=C1)=O

MicroRNA

10 mM in DMSO

Room temperature