Lipid 114
Lipid 114
SKU:QM-0010134
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Product Details
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Description
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. Lipid 114 can be used to generate lipid nanoparticles (LNP) to deliver siRNA in vitro as well as in vivo. Lipid 114 LNPs encapsulating siRNA that targets IL-1β can reduce IL-1β expression in macrophages. Lipid 114 LNPs encapsulating siRNA that targets IL-1β also reduces hepatic and renal expression of IL-1β, as well as decreasing hepatic inflammation in mouse model with LPS-induced acute liver failure[1].
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Molecular Formula
C95H186N4O10
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Molecular Weight
1544.51
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Smiles
CCCCCCCCCCCCCCOC(CCN(CCCNCCCCN(CCC(OCCCCCCCCCCCCCC)=O)CCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O
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Target
Liposome
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Shipping Conditions
Room temperature
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Lipid 114
Lipid 114 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.