Lipid C2 [CAS 3003022-09-8]
Lipid C2 [CAS 3003022-09-8]
SKU:QM-0008861
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Product Details
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Description
Lipid C2 is an ionizable cationic lipid that has been used in the formation of lipid nanoparticles (LNP) for mRNA delivery in vivo. LNPs containing Lipid C2 and encapsulating an mRNA reporter selectively accumulate in the liver and spleen but not the heart, lungs, or kidneys in mice. LNP containing Lipid C2 and encapsulating mRNA encoding the Epstein-Barr virus (EBV) protein latent membrane protein 2 (LMP-2), in combination with an anti-programmed cell death protein 1 (PD-1) antibody, decrease tumor volume and reverse T cell exhaustion, as well as increase the percentage of CD3+CD8+ central and CD3+CD8+ effector memory T cells and decrease the percentage of CD3+ T cells expressing Pd-1, in the spleen in a CT26 murine EBV-infected colon cancer model[1].
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CAS Number
[3003022-09-8]
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Molecular Formula
C70H142N6O6
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Molecular Weight
1163.91
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Smiles
O=C(CCN1CCN(CC1)CCC(NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O)=O)NCCN(CC(CCCCCCCCCCCC)O)CC(CCCCCCCCCCCC)O
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Target
Liposome
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Shipping Conditions
Room temperature
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Lipid C2 [CAS 3003022-09-8]
Lipid C2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.