LIQ1 [CAS 2606032-80-6]

LIQ1, a flavonoid derivative, is a potent Pyruvate kinase M2 (PKM2) allosteric inhibitor (IC50 = 0.39 μM; Kd = 4.5 μM) targeting Arg43 within the polyarginine pocket. LIQ1 exhibits efficacy in a mouse model of LPS -induced endotoxemia, preventing the nuclear translocation of PKM2 and inhibiting its binding to HIF-1α, thereby suppressing IL-1β transcription. LIQ1 can be used for the research of endotoxemia[1].

[2606032-80-6]

C16H12O5

284.26

O=C(C1=CC=CC=C1C2CC(C3=CC=C(C=C3O2)O)=O)O

Interleukin Related; Pyruvate Kinase

PKM2

Room temperature