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Lirafugratinib [CAS 2549174-42-5]
Lirafugratinib [CAS 2549174-42-5]
SKU:QM-0149299-01
£376.83 GBP
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Product Details
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Description
Lirafugratinib (RLY-4008) is an orally active, irreversible and highly selective FGFR2 inhibitor with an IC50 of 3 nM. Lirafugratinib covalently binds to Cys491. Lirafugratinib targets FGFR2 primary alterations and resistance mutations and induces tumor regression while sparing other FGFRs[1].
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CAS Number
[2549174-42-5]
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Molecular Formula
C28H24FN7O2
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Molecular Weight
509.53
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Smiles
O=C(C(C)=C)NC1=CC=C(C2=C(C3=C(N)N=CN=C3N2C)C4=CC(F)=C(OC5=NC=CC(C)=N5)C=C4)C=C1
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Target
FGFR
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Concentration
10mM
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Purity
99.67
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Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Lirafugratinib [CAS 2549174-42-5]
Lirafugratinib is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.