LL-K8-22 [CAS 3034487-84-5]

LL-K8-22 is a potent, selective and durable PROTAC CDK8-cyclin C dual degrader, with DC50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research. (Pink: Ligand for target protein ; Black: Linker (HY-Y0340) ; Blue: Ligand for E3 ligase (HY-N2427) ).

[3034487-84-5]

C37H43N5O

573.77

O=C(CN1C=C(C2=CC=C(C3=CN=CC4=CC=CC=C43)C=C2)C=N1)N5CCN(CCCC67CC8CC(CC(C8)C7)C6)CC5

CDK; Early 2 Factor (E2F) ; PROTACs; STAT

CDK8; STAT1

99.76

DMSO : 125 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice