LLC0424

LLC0424 is a potent and selective cereblon-based PROTAC nuclear receptor-binding SET domain-containing 2 (NSD2) degrader. LLC0424 effectively degraded NSD2 with a DC50 of 20 nM in RPMI-8402 cells. LLC0424 selectively induces NSD2 degradation in a cereblon- and proteasome-dependent fashion. (Blue: CRBN ligand , Black: linker (HY-40002) ; Pink: NSD2 inhibitor (HY-161575) ).

C45H41N7O9

823.85

O=C(N1)COC2=C1C=CC(C(N(C3CC3)CC4=CC=C(C(NC5=CC=C(C(NC6CCN(C7=CC8=C(C(N(C(C(N9)=O)CCC9=O)C8=O)=O)C=C7)CC6)=O)C=C5)=O)C=C4)=O)=C2

Histone Methyltransferase; PROTACs

Cereblon; NSD2/MMSET/WHSC1

98.42

DMSO : ≥ 100 mg/mL

-20°C (Powder, stored under nitrogen)

Blue Ice