LLY-283 [CAS 2040291-27-6]

LLY-283, a chemical probe, is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity[1].

[2040291-27-6]

C17H18N4O4

342.35

O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC=CC=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3

Histone Methyltransferase

PRMT5

10mM

98.93

DMSO : 100 mg/mL (ultrasonic) |H2O : 3.57 mg/mL (ultrasonic; warming; heat to 60°C)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature