LM-189

LM-189, a G protein alpha subunit I (Gαi) -biased agonist, is a Gαi-biased ligand of β2-adrenergic receptor (β2AR) . LM-189 stabilizes a distinct conformation in TM6 and increases the dynamics of ICL2. LM-189 can be used to develop the Gαi-biased β2AR agonists[1].

C26H36F3NO6

515.56

OC1=CC=C([C@@H](O)CNCCCCCCOCCCCC2=CC=CC=C2)C=C1O.O=C(O)C(F)(F)F

Adrenergic Receptor

β adrenergic receptor

96.58

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years (Powder)

Blue Ice