LMP7/LMP2-IN-1 [CAS 3053755-09-9]

LMP7/LMP2-IN-1 (Compound 19) is the orally active inhibitor for immunoproteasome subunits LMP7 and LMP2 with IC50 of 257 and 10 nM. LMP7/LMP2-IN-1 reduces the generation of antibody, downregulates the cells in spleen germinal center B and in plasma in NP-OVA-immunized mice, and can be used in research about autoimmune diseases[1].

[3053755-09-9]

C16H27BN4O3

334.22

OB(O)[C@@H](NC(C1=CN(C2CCCCC2)N=N1)=O)C3CCCCC3

Proteasome

Room temperature