LN-1-255 (sodium) [CAS 247115-03-3]

LN-1-255 sodium is a β-lactamase inhibitor. LN-1-255 sodium has broad-spectrum inhibitory effect on type D carbapenemases (CHDLs) with an IC50 for OXA-48 of 3 nM, and it also has strong activity against OXA-23, OXA-24/40, etc. LN-1-255 sodium combined with carbapenem antibiotics has a synergistic effect. LN-1-255 sodium can be used to study the bacterial resistance crisis caused by CHDLs[1][2].

[247115-03-3]

C22H19N2NaO9S

510.45

O=C([C@@H]([C@](C)(COC(CC1=CC=C(O)C(O)=C1)=O)S([C@]2([H])/C3=C\C4=NC=CC=C4)(=O)=O)N2C3=O)O[Na]

Bacterial; Beta-lactamase

Room temperature