Lometrexol (disodium) [CAS 120408-07-3]

Lometrexol (DDATHF) disodium, an antipurine antifolate, can inhibit the activity of glycinamide ribonucleotide formyltransferase (GARFT) but do not induce detectable levels of DNA strand breaks. Lometrexol disodium can further inhibit de novo purine synthesis, causing abnormal cell proliferation and apoptosis, even cell cycle arrest. Lometrexol disodium has anticancer activity. Lometrexol disodium also is a potent human Serine hydroxymethyltransferase1/2 (hSHMT1/2) inhibitor[1][2][3].

[120408-07-3]

C21H23N5Na2O6

487.42

O=C1C2=C(NC[C@H](CCC3=CC=C(C(N[C@@H](CCC(O[Na])=O)C(O[Na])=O)=O)C=C3)C2)N=C(N)N1

Antifolate; Apoptosis; Bcl-2 Family; Caspase

98

H2O : 100 mg/mL (ultrasonic)

-20°C (Powder, sealed storage, away from moisture)

Blue Ice