LPPM-8

LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs) . LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a) . LPPM-8 can be used for studying Med25 and Mediator complex biology[1].

C50H89N7O14

1012.28

CCCCCCCC[C@H]([C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(C)C)C(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CC(O)=O)=O)CCC(O)=O)=O)C)O

ATF6

10 mM in DMSO

Room temperature