LSD1-IN-31

LSD1-IN-31 (compound 11e) can directly bind to LSD1/CoREST complex to reduce LSD1 demethylation enzymatic activity. LSD1-IN-31 inhibits LSD1 demethylation activity and influences its downstream IκB/NF-κB signaling pathway. LSD1-IN-31 inhibits osteoclastic bone loss in vitro and in vivo. LSD1-IN-31 can be used for osteoporosis research[1].

C36H57ClN2O3Si2

657.47

O=C(N1CCC(CN[C@H]2[C@H](C3=CC=CC=C3)C2)CC1)/C=C/C4=CC(O[Si](C)(C)C(C)(C)C)=C(O[Si](C)(C)C(C)(C)C)C=C4.Cl

Histone Demethylase

KDM1/LSD1

Room temperature