LSD1-IN-43

LSD1-IN-43 is a highly selective, reversible, orally active and brain-penetrant LSD1 inhibitor with an IC50 value of 0.8 μM. LSD1-IN-43 has low inhibitory activity against MAO-A and MAO-B, two homologs of LSD1. LSD1-IN-43 significantly inhibits Aβ aggregation and enhances Aβ-induced neuronal cell viability. LSD1-IN-43 can be used for the study of Alzheimer’s disease (AD) [1].

C23H23NO4

377.43

C[C@@]12[C@](CC(C3=C2)=C(C)C(O3)=O)([H])C(CC4=CNC5=C4C(O)=CC=C5)C(CC1)=O

Amyloid-β; Histone Demethylase

KDM1/LSD1

Room temperature