LT175 [CAS 862901-87-9]

LT175, a dual PPARα/γ ligand, is an orally active partial agonist against PPARγ (hPPARα:EC50=0.22 μm; mPPARα:EC50=0.26 μm; hPPARγ:EC50=0.48 μm) . LT175 interacts with PPARγ and affects the recruitment of the coregulators cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1 (NCoR1) . LT175 interacts with PPARγ in a hydrophobic region called "diphenyl pocket" . LT175 has potent insulin-sensitizing effects and reduced adipogenic properties[1].

[862901-87-9]

C21H18O3

318.37

O=C([C@@H](OC1=CC=C(C2=CC=CC=C2)C=C1)CC3=CC=CC=C3)O

PPAR

PPARα; PPARγ

99.79

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature

H301-H312-H330-H410

P264-P270-P330-P405-P501