Lu AF58786 [CAS 1632368-13-8]

Lu AF58786 is a potent and selective LRRK2 inhibitor with an IC50 of 12 nM. Lu AF58786 also exhibits inhibition activity against LRRK2 G2019S and LRRK2 A2016T with IC50s of 19 and 93 nM. Lu AF58786 inhibits phosphorylation of LRRK2, Rab10 and Rab12 in human peripheral blood mononuclear cells. Lu AF58786 can be used for parkinson’s disease research[1][2].

[1632368-13-8]

C19H16N6

328.37

N#CC1=CNC2=NC(NC3=NN(C)C=C3)=CC(C4=CC(C)=CC=C4)=C12

LRRK2

Room temperature