Lumichrome-d8

Lumichrome-d8 is the deuterium labeled Lumichrome. Lumichrome, a photodegradation product of Riboflavin, is an endogenous compound in humans. Lumichrome inhibits human lung cancer cell growth and induces apoptosis via a p53-dependent mechanism. Lumichrom is the inhibitor for AKT/β-catenin signaling pathway[1][2].

C12H2D8N4O2

250.28

O=C(N1)C2=NC3=C(C(C([2H])([2H])[2H])=C(C([2H])=C3N=C2NC1=O)C([2H])([2H])[2H])[2H]

Akt; Apoptosis; ERK; Isotope-Labeled Compounds; MDM-2/p53; NF-κB; Nuclear Factor of activated T Cells (NFAT) ; p38 MAPK

Room temperature