LY 178210 [CAS 114943-19-0]

LY 178210 (Compound 24) is a selective partial agonist of the 5-HT1A receptor, with Ki values ​​of 0.67 and 380 nM for the 5-HT1A and 5-HT1D receptors, respectively. LY 178210 has almost no activity against α₂-adrenergic receptors, 5-HT₂, and other neurotransmitter receptors. LY 178210 inhibits Foscolin-stimulated cyclase activity, but its maximum potency is lower than that of the full agonist 8-OH-DPAT. LY 178210 significantly reduces 5-hydroxyindoleacetic acid (5-HIAA) levels in the greater hypothalamus and increases serum corticosterone concentrations[1][2].

[114943-19-0]

C18H25N3O

299.41

O=C(C1=C2C3=C(NC=C3CC(N(CCC)CCC)C2)C=C1)N

5-HT Receptor

5-HT1 Receptor

Room temperature