LY256548 [CAS 107889-31-6]

LY256548 (LY25648) is an orally available anti-ischemic and anti-inflammatory compound with central nervous system activity. LY256548 is an inhibitor of phospholipase A2, 5-lipoxygenase (5-LOX), and COX, and inhibits A23187 -stimulated leukotriene B4 production. LY256548 inhibits bone damage and paw swelling in the rat Freund's complete adjuvant-induced arthritis (FCA) model[1][2].

[107889-31-6]

C19H27NO2S

333.49

O=C1N(CS/C1=C\C2=CC(C(C)(C)C)=C(C(C(C)(C)C)=C2)O)C

COX; Leukotriene Receptor; Lipoxygenase; Phospholipase

5-LOX; COX; LTB4; Phospholipase A

Room temperature