LY2886721 [CAS 1262036-50-9]

LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM) . LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment[1].

[1262036-50-9]

C18H16F2N4O2S

390.41

FC1=CN=C(C=C1)C(NC2=CC=C(C([C@@]34[C@]([H])(CSC(N)=N4)COC3)=C2)F)=O

Beta-secretase

BACE1

99.72

DMSO : ≥ 16.67 mg/mL

-20°C, 3 years (Powder)

Blue Ice

H302, H315, H319, H335

H302, H315, H319, H335