LZ-07

LZ-07 is a IRAK4 PROTAC degrader (DC50 = 1.14 nM). LZ-07 leads to marked suppression of cytokines including IL-6, IL-1β, TNF-α, and IL-10 upon degradation of IRAK4. LZ-07 can be studied in research for autoimmune diseases (Pink: IRAK4 ligand ; Blue: CRBN ligand (HY-34590) ; Black: linker (HY-B0149) ; CRBN ligand + linker: HY-172593).

C42H48N14O4

812.92

CC1(CC1)NC2=NC(NC3=CN(C4CCN(C([C@@H]5CC[C@@H](CNC6=CN=C(C(NC7CCC(NC7=O)=O)=O)C=C6)CC5)=O)CC4)N=C3)=NC8=CC=C(C9=CN=CN=C9)N=C82

Interleukin Related; IRAK; PROTACs; TNF Receptor

Room temperature