MA242 (free base) [CAS 1049704-17-7]

MA242 free base is a specific dual inhibitor of MDM2 and NFAT1. MA242 free base directly binds both MDM2 and NFAT1 with high affinity, induces their protein degradation, and inhibits NFAT1-mediated transcription of MDM2. MA242 free base induces apoptosis in pancreatic cancer cell lines regardless of p53 status[1].

[1049704-17-7]

C24H20ClN3O3S

465.95

O=C1C(NCC2=CC=C(C=C2)Cl)=CC3=NCCC4=CN(S(=O)(C5=CC=C(C)C=C5)=O)C1=C34

Apoptosis; MDM-2/p53

10 mM in DMSO

Room temperature