MAC glucuronide phenol-linked SN-38 [CAS 2246380-69-6]
MAC glucuronide phenol-linked SN-38 [CAS 2246380-69-6]
SKU:QM-0142715-01
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Product Details
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Description
MAC glucuronide phenol-linked SN-38 is a pH-susceptible lactone MAC glucuronide phenol-linked SN-38 (DNA topoisomerase I inhibitor) agent linker. MAC glucuronide phenol-linked SN-38 is cytotoxic across L540cy cells and Ramos cells with IC50 values of 113 and 67 ng/mL, respectively.Albumin-coupled MAC glucosidol-linked SN-38 shows good stability in mouse plasma[1][2].
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CAS Number
[2246380-69-6]
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Molecular Formula
C50H54N6O20S
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Molecular Weight
1091.06
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Smiles
O=C([C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(COC(N(COC3=CC=C4N=C5C(CN6C(C(COC([C@@]7(CC)O)=O)=C7C=C65)=O)=C(CC)C4=C3)CCS(=O)(C)=O)=O)C=C2NC(CN(C)C(CCN8C(C=CC8=O)=O)=O)=O)O1)O
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Target
Drug-Linker Conjugates for ADC
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Isoform
Camptothecins
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Purity
99.5
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Blue Ice
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MAC glucuronide phenol-linked SN-38 [CAS 2246380-69-6]
MAC glucuronide phenol-linked SN-38 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.