Mambalgin-2

Mambalgin-2 (Mamb-2) is an acid-sensitive ion channels (ASICs) inhibitor and a venom peptide. Mambalgin-2 can be obtained from the venom of the African black mamba. Mambalgin-2 can be used in the study of pain and neurological diseases[1].

C272H431N85O83S10

6540.5

O=C(C(N)CC(C)C)NC(C(N[C@H](C(NC(C(N[C@H](C(NC(C(NCC(NC(C(NC(C(N[C@H](C(N[C@@H](C(N[C@@H](C(N[C@H](C(NC(C(NC(C(NC(C(NC(C(N[C@H]1CC2=CC=CC=C2)=O)CCCCN)=O)CCSC)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CC3=CNC=N3)=O)CS)=O)[C@H](C)O)=O)C(C)C)=O)C(C)C)=O)CCCCN)=O)=O)CC4=CNC=N4)=O)CCC(N)=O)=O)CC5=CC=CC=C5)=O)CSSCC(NC1=O)C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(N6[C@H](C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NCC(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(NC(C(N[C@@H](C(NC(C(NC(C(NC(C(NC7CCCCN)=O)CC(N)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)C(C)O)=O)CCC(O)=O)=O)CO)=O)CSSCC(NC7=O)C(NC(C(NC(C(NC(C(NC(C(NC8CCCNC(N)=N)=O)CC(O)=O)=O)C(C)O)=O)CO)=O)CSSCC(NC8=O)C(NC(C(NC(C(O)=O)CCCCN)=O)CC(N)=O)=O)=O)=O)CO)=O)CO)=O)CO)=O)CS)=O)=O)CCC(N)=O)=O)CC(C)C)=O)C(CC)C)=O)CC(C)C)=O)CCCCN)=O)CC(C)C)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CC9=CC=CC=C9)=O)CCC6)=O)CCSC)=O)=O)C(C)O)=O)CC(N)=O)=O)CC%10=CNC=N%10)=O)CC%11=CC=C(O)C=C%11)=O)=O)CCCCN

Sodium Channel

10 mM in DMSO

Room temperature