MAO-B-IN-30 (compound IS7) is a potent, selective and cross the blood-brain barrier MAO-B inhibitor with IC50 values of 19.176, 0.082 µM for MAO-A and MAO-B, respectively. MAO-B-IN-30 shows antiproliferative activity and non-cytotoxic. MAO-B-IN-30 reduces TNF-alpha, IL-6, NF-kB levels. MAO-B-IN-30 has the potential for the research of Parkinson's disease[1].
CAS Number
[82973-15-7]
Molecular Formula
C15H10BrN3O2
Molecular Weight
344.16
Smiles
O=C(/C1=N\NC(C2=CC=C(Br)C=C2)=O)NC3=C1C=CC=C3
Target
Monoamine Oxidase
Isoform
MAO-A; MAO-B
Purity
98.53
Solubility
DMSO : 4.17 mg/mL (ultrasonic; warming; heat to 60°C)