MAO-B-IN-33 [CAS 2286257-25-6]

MAO-B-IN-33 (compound C3) is a potent, reversible and selective monoamine oxidase-B (MAO-B) inhibitor with an IC50 of 0.021 μM and 26.805 μM for MAO-B and MAO-A, respectively. The selectivity of MAO-B-IN-33 is attributed to the steric clash arising from the residue differences between Phe208 (MAO-A) and Ile199 (MAO-B). MAO-B-IN-33 inhibits cerebral MAO-B activity and alleviates MPTP -induced dopaminergic neuronal loss in the mouse. MAO-B-IN-33 has the potential for Parkinson's disease research[1].

[2286257-25-6]

C18H19FN2O2

314.35

NC([C@@H]1CCN1CC2=CC=C(OCC3=CC(F)=CC=C3)C=C2)=O

Monoamine Oxidase

MAO-A; MAO-B

Room temperature