MAO-B-IN-49 [CAS 3098883-91-8]

MAO-B-IN-49 is a selective and reversible MAO-B inhibitor (IC50 of 1 nM for human MAO-B). MAO-B-IN-49 shows much higher selectivity for MAO-B than for MAO-A (IC50 = 633.9). MAO-B-IN-49 can reduce ROS production induced by Lipopolysaccharides (LPS) in HT22 cells. MAO-B-IN-49 demonstrates substantial neuroprotective properties and significantly improves motor dysfunction in MPTP (HY-W114750) -induced mouse models of Parkinson’s disease (PD). MAO-B-IN-49 can be used for the study of PD[1].

[3098883-91-8]

C19H20F2N2O3

362.37

C[C@H](N1CCOC2=C(C1)C=CC(OCC3=CC(F)=C(C=C3)F)=C2)C(N)=O

Monoamine Oxidase; Reactive Oxygen Species (ROS)

Room temperature