MAP855 [CAS 1660107-77-6]

MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM) . MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2[1].

[1660107-77-6]

C28H23ClF2N6O3

564.97

CC1=NC2=C(C3=CC(C4=C(C=C(C=C4)OC5=NC=CC=N5)Cl)=C(F)C=C3N=C2)N1[C@]6([H])[C@H](CN(CC6)C(CO)=O)F

ERK; MEK

ERK; MEK1

98.48

DMSO : 100 mg/mL (ultrasonic)

-20°C, 3 years; 4°C, 2 years (Powder)

Room Temperature