MARK-IN-4 [CAS 1990492-86-8]

MARK-IN-4 is a potent microtubule affinity regulating kinase (MARK) inhibitor with an IC50 of 1 nM. Inhibition of microtubule affinity regulating kinase (MARK) represents a potentially attractive means of arresting neurofibrillary tangle pathology in Alzheimer's disease[1].

[1990492-86-8]

C21H23N7OS

421.52

O=C(C1=CC(C2=C3N=CC(C4=CN(C)N=C4)=CN3N=C2)=CS1)N[C@H]5[C@H](N)CCCC5

AMPK; MARK

10mM

99.63

DMSO : 100 mg/mL (ultrasonic)

-20°C (Powder, protect from light, stored under nitrogen)

Blue Ice