MAT2A-IN-14

MAT2A-IN-14 (compound H3) is a MAT2A inhibitor, and generates reactive oxygen species after sonication to specifically degrade cellular MAT2A via rapid oxidative reactions. Combination of MAT2A-IN-14 and sonication induces 87% MAT2A depletion in human colon cancer cell[1].

C27H24F2N4O4

506.5

O=C1C(C2=CC=C(C3=C2)OCC4N3CCC4)=CC(C=NC(OCC)=N5)=C5N1C6=CC=C(C=C6)OC(F)F

Methionine Adenosyltransferase (MAT) ; Reactive Oxygen Species (ROS)

10 mM in DMSO

Room temperature