MAT2A-IN-24 [CAS 3031093-57-6]

MAT2A-IN-24 (Compound 9) is an inhibitor of methionine adenosyltransferase 2a (MAT2a) . The IC50 value for the inhibition of MAT2a is 20 nM, and the IC50 value for the antiproliferative activity against HAP1MTAP–/– cells is 10 nM. MAT2A-IN-24 can be used in the research field of tumor diseases associated with MTAP deficiency[1].

[3031093-57-6]

C32H33Cl2N7O2

618.56

CN(C)C(C1=C(N2C3=CC=CC(N4CCC(CN5C(C=C(Cl)C=C6)=C6C(N(C)C)=NC5=O)CC4)=C3)C=C(Cl)C=C1)=NC2=O

Methionine Adenosyltransferase (MAT)

Room temperature