Mazdutide (IBI-362; LY-3305677) TFA is a long-acting synthetic oxyntomodulin analog. Mazdutide is also a co-agonist of glucagon-like peptide (GLP-1R) and glucagon receptor (GCGR) . Mazdutide TFA binds human and mouse GCGR (Ki: 17.7 nM and 15.9 nM, respectively) and GLP-1R (Ki: 28.6 nM and 25.1 nM, respectively) and stimulates insulin secretion from mouse islets (EC50: 5.2 nM) . Mazdutide TFA is used in studies of obesity and type 2 diabetes (T2D) [1][2][3].
Molecular Formula
C210H322N46O67.xC2HF3O2
Smiles
[Mazdutide(TFA)]
Target
GCGR; GLP Receptor
Purity
99.67
Solubility
DMSO : 100 mg/mL (ultrasonic)
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
