MC-GGFG-AM- (10Me-11F-Camptothecin) [CAS 2873460-70-7]
MC-GGFG-AM- (10Me-11F-Camptothecin) [CAS 2873460-70-7]
SKU:QM-0151118-01
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Product Details
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Description
MC-GGFG-AM- (10Me-11F-Camptothecin) is a linker-payload conjugate used to synthesize ZW251. ZW251 an antibody-drug conjugate (ADC) targeting human GPC3. ZW251 consists of a humanized IgG1 antibody conjugated to a novel camptothecin-based topoisomerase 1 inhibitor, ZD06519, via a linker. The linker is the maleimide anchor and a glycyl glycyl phenylalanyl glycine (GGFG) -aminomethyl (AM) cleavable linker. ZW251 has high affinity with human and cynomolgus monkey GPC3. ZW251 displays rapid internalization in GPC3-expressing HCC cell lines, and bystander-mediated killing of GPC3 negative cancer cells[1].
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CAS Number
[2873460-70-7]
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Molecular Formula
C51H56FN9O14
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Molecular Weight
1038.04
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Smiles
FC1=C(C)C=C2C(CNC(OCCOCNC(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)=O)=C5C(C(N6C5)=CC([C@@](O)(CC)C(OC7)=O)=C7C6=O)=NC2=C1
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Target
Drug-Linker Conjugates for ADC; Topoisomerase
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Isoform
Topo I
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Purity
98.99
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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MC-GGFG-AM- (10Me-11F-Camptothecin) [CAS 2873460-70-7]
MC-GGFG-AM- (10Me-11F-Camptothecin) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.