Mca-SEVNLDAEFK (Dnp) [CAS 1802078-31-4]

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SKU:QM-0080008

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Description
Mca-SEVNLDAEFK (Dnp) is a Beta-secretase 1 (BACE-1) peptide FRET substrate, containing the 'Swedish' Lys-Met/Asn-Leu mutation of the amyloid precursor protein (APP) β-secretase cleavage site. Cleavage at -Leu-Asp- of Mca-SEVNLDAEFK (Dnp) liberates the highly fluorescent 7-methoxycoumarin (Mca) fragment from the proximity quenching effect of the 2,4-dinitrophenyl (Dnp) internal quencher resulting in a large and easily detectable increase in fluorescence intensity.
CAS Number
[1802078-31-4]
Molecular Formula
C68H88N14O27
Molecular Weight
1533.5
Smiles
O=[N+]([O-])C(C=C(C=C1)[N+]([O-])=O)=C1NCCCC[C@@H](C(O)=O)NC([C@H](CC2=CC=CC=C2)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CO)NC(CC(C3=CC=C(OC)C=C3O4)=CC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Target
Beta-secretase
Solubility
10 mM in DMSO
Shipping Conditions
Room temperature

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Mca-SEVNLDAEFK (Dnp) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.