Mcl1-IN-15 [CAS 518303-27-0]

Mcl1-IN-15 (Compound 7) is the inhibitor for myeloid cell leukemia 1 (Mcl-1) with an IC50 of 8.73 μM. Mcl1-IN-15 inhibits Mcl1-BH3 peptide interaction, activates the Bak/Bax-mediated apoptosis and exhibits antitumor activity[1].

[518303-27-0]

C22H23NO5S2

445.55

O=C(O)CSC1=CC(NS(=O)(C2=CC=C(C(C)(C)C)C=C2)=O)=C3C=CC=CC3=C1O

Apoptosis; Bcl-2 Family

Mcl-1

Room temperature

H302-H315-H319-H335

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501