Me4Phen

Me4Phen (compound 3) is an oxygen rhenium (V) complex that depletes mitochondrial membrane potential and upregulates intracellular reactive oxygen species (ROS), leading to endoplasmic reticulum stress-mediated necrosis of cancer cells. Me4Phen is highly lipophilic and effectively overcomes Cisplatin resistance in a variety of cancer cells[1].

C18H20ClN2O3Re

534.02

CC1=C(C)C(C=CC2=C3[N]([Re]45(OCCO5)(Cl)=O)=CC(C)=C2C)=C3[N]4=C1

Apoptosis

10 mM in DMSO

Room temperature