MEN 10207 (acetate)

MEN 10207 (acetate) is a selective antagonist of the NK-2 tachykinin receptor. MEN 10207 (acetate) induces tachykinin-induced contractions in rat bladder and guinea pig airways in vivo. MEN 10207 (acetate) inhibits [β-Ala 8 ]-NKA (4-10) -induced enhancement of bladder motility in anesthetized rats and [β-Ala 8 ]-NKA (4-10) -induced enhancement of bronchoconstriction in anesthetized guinea pigs[1].

C57H68N14O10.xC2H4O2

1109.24

N=C(NCCC[C@H](NC([C@H](NC([C@@H](CC1=CNC2=CC=CC=C12)NC([C@@H](NC([C@@H](CC3=CNC4=CC=CC=C34)NC([C@H](CC5=CC=C(O)C=C5)NC([C@H](CC(O)=O)N)=O)=O)=O)C(C)C)=O)=O)CC6=CNC7=CC=CC=C67)=O)C(N)=O)N.CC(O)=O.[x]

Neurokinin Receptor

NK2R

Room temperature