MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].
CAS Number
[2308548-54-9]
Molecular Formula
C14H16N4O2S
Molecular Weight
304.37
Smiles
COC1=CC=C(NC(/C2=N\NC(N3CCCC3)=S)=O)C2=C1
Target
MDM-2/p53
Purity
99.84
Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)